ALERT: This system is being upgraded on Tuesday December 12. It will not be available
for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace
will be disabled on Monday December 11, so no new items are to be added to the repository
while the upgrade is in progress. Everything should be back to normal by the end of
day, December 12.
Browsing by Author "Klitzman, Bruce"
Now showing items 1-14 of 14
-
A model of sequential heart and composite tissue allotransplant in rats.
(Plast Reconstr Surg, 2010-07)BACKGROUND: Some of the 600,000 patients with solid organ allotransplants need reconstruction with a composite tissue allotransplant, such as the hand, abdominal wall, or face. The aim of this study was to develop a rat ... -
Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.
(PLoS One, 2014)Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of ... -
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.
(eLife, 2018-06-19)How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed ... -
Bioburden after Staphylococcus aureus inoculation in type 1 diabetic rats undergoing internal fixation.
(Plast Reconstr Surg, 2014-09)SUMMARY: Fracture stabilization in the diabetic patient is associated with higher complication rates, particularly infection and impaired wound healing, which can lead to major tissue damage, osteomyelitis, and higher amputation ... -
Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants.
(J Diabetes Sci Technol, 2010-09-01)BACKGROUND: The bioluminescence technique was used to quantify the local glucose concentration in the tissue surrounding subcutaneously implanted polyurethane material and surrounding glucose sensors. In addition, some implants ... -
Characterization of the Foreign Body Response to Common Surgical Biomaterials in a Murine Model.
(European journal of plastic surgery, 2017-11)BACKGROUND:Implanted biomaterials are subject to a significant reaction from the host, known as the foreign body response (FBR). We quantified the FBR to five materials following subcutaneous implantation in mice. MATERIALS ... -
Enhanced Drug Delivery to the Skin Using Liposomes.
(Plastic and reconstructive surgery. Global open, 2018-07-09)Enhancing drug delivery to the skin has importance in many therapeutic strategies. In particular, the outcome in vascularized composite allotransplantation mainly depends on systemic immunosuppression to prevent and treat ... -
In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene.
(Curr Eye Res, 2011-02)PURPOSE: Long-term intraocular pressure reduction by glaucoma drainage devices (GDDs) is often limited by the fibrotic capsule that forms around them. Prior work demonstrates that modifying a GDD with a porous membrane promotes ... -
Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia.
(Scientific reports, 2017-08-15)Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood ... -
Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials.
(Ann Biomed Eng, 2010-06)Resorbable scaffolds such as polyglycolic acid (PGA) are employed in a number of clinical and tissue engineering applications owing to their desirable property of allowing remodeling to form native tissue over time. However, ... -
Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo.
(Ann Biomed Eng, 2017-06)Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold's mechanical properties may help to optimize neovascularization within implanted biomaterials. However, ... -
The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants.
(Biomaterials, 2012-09)Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates ... -
Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability.
(Wound Repair Regen, 2012-11)Adipose-derived stem cells (ASCs) have the ability to release multiple growth factors in response to hypoxia. In this study, we investigated the potential of ASCs to prevent tissue ischemia. We found conditioned media from ... -
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
(Advances in experimental medicine and biology, 2017-01)We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have ...
