Browsing by Author "Koh, James"
Now showing items 1-4 of 4
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A Novel Ex Vivo Method for Visualizing Live-Cell Calcium Response Behavior in Intact Human Tumors.
(PLoS One, 2016)The functional impact of intratumoral heterogeneity has been difficult to assess in the absence of a means to interrogate dynamic, live-cell biochemical events in the native tissue context of a human tumor. Conventional ... -
Parathyroid‐Targeted Overexpression of Regulator of G‐Protein Signaling 5 (RGS5) Causes Hyperparathyroidism in Transgenic Mice
(Journal of Bone and Mineral Research, 2019-05) -
Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism.
(J Cell Mol Med, 2016-02)Primary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder caused by a failure of calcium sensing secondary to tumour development in one or more of the parathyroid glands. Parathyroid adenomas are comprised ... -
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.
(Genome Biol, 2015-09-17)BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of ...
