Browsing by Author "Kraus, Virginia B"
Now showing items 1-20 of 38
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A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic ... -
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.
(The journals of gerontology. Series A, Biological sciences and medical sciences, 2018-05-22)Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first ... -
Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.
(Arthritis research & therapy, 2018-04-18)BACKGROUND:Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and ... -
Association of Biomarkers with Individual and Multiple Body Sites of Pain: The Johnston County Osteoarthritis Project.
(Journal of pain research, 2022-01)<h4>Introduction</h4>Biochemical biomarkers may provide insight into musculoskeletal pain reported at individual or multiple body sites. The purpose of this study was to determine if biomarkers or pressure-pain threshold ... -
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
(PLoS One, 2012)OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or ... -
Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.
(Osteoarthritis and cartilage, 2004-05)To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis.Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig ... -
Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.
(Open Orthop J, 2012)Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, and even midbrain, ... -
Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).
(Arthritis Res Ther, 2010)INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ... -
Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.
(Trials, 2015-04-30)BACKGROUND: Despite the high prevalence and global impact of knee osteoarthritis (KOA), current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. We recently demonstrated ... -
Collagen biomarkers for arthritis applications.
(Biomark Insights, 2007-02-07) -
Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.
(Journal of the American Geriatrics Society, 2018-05-08)To determine whether combinations of inflammatory markers are related to physical function.secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data ... -
CXCL10 is Upregulated in Synovium and Cartilage following Articular Fracture.
(J Orthop Res, 2017-09-14)The objective of this study was to investigate the expression of the chemokine CXCL10 and its role in joint tissues following articular fracture. We hypothesized that CXCL10 is upregulated following articular fracture and ... -
Cytokine biomarkers in tear film for primary open-angle glaucoma.
(Clin Ophthalmol, 2017)PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from ... -
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ... -
Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study.
(Nutrients, 2018-04-09)Although dietary patterns are crucial to cognitive function, associations of dietary patterns with cognitive function have not yet been fully understood. This cross-sectional study explored dietary patterns associated with ... -
Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.
(Arthritis research & therapy, 2018-12-27)BACKGROUND:Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training ... -
Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study.
(The Journal of bone and joint surgery. American volume, 2018-04)Intra-articular corticosteroids relieve osteoarthritis pain, but rapid systemic absorption limits efficacy. FX006, a novel, microsphere-based, extended-release triamcinolone acetonide (TA) formulation, prolongs TA joint ... -
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, ... -
Gender-dependent association of body mass index and waist circumference with disability in the Chinese oldest old.
(Obesity (Silver Spring), 2014-08)OBJECTIVES: To explore associations of BMI and waist circumference (WC) with disability among the Chinese oldest old. METHODS: The 5,495 oldest old in the sixth wave of Chinese Longitudinal Healthy Longevity Study conducted ...
