Now showing items 1-3 of 3

    • Disease Modification of Epilepsy by Disruption of TrkB Signaling 

      Krishnamurthy, Kamesh (2019)
      Epilepsy is the most common acquired neurological disorder and is characterized by spontaneous, recurrent seizures. Of the various forms of epilepsy, Temporal Lobe Epilepsy (TLE) has received intense clinical and research ...
    • Regression of Epileptogenesis by Inhibiting Tropomyosin Kinase B Signaling following a Seizure. 

      Krishnamurthy, Kamesh; Huang, Yang Zhong; Harward, Stephen C; Sharma, Keshov K; Tamayo, Dylan L; McNamara, James O (Annals of neurology, 2019-12)
      OBJECTIVE:Temporal lobe epilepsy (TLE) is a devastating disease in which seizures persist in 35% of patients despite optimal use of antiseizure drugs. Clinical and preclinical evidence implicates seizures themselves as one ...
    • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 

      Huang, Yang Zhong; He, Xiao-Ping; Krishnamurthy, Kamesh; McNamara, James O (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-06)
      Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of de novo prolonged seizures [status epilepticus (SE)]. ...