Browsing by Author "Lee, Whasil"

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    • Nanomechanics of Ankyrin Repeat Proteins 

      Lee, Whasil (2011)
      Ankyrin repeats (ARs) are polypeptide motifs identified in thousands of proteins. Many AR proteins play a function as scaffolds in protein-protein interactions which may require specific mechanical properties. Also, a number ...

    • Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. 

      Kanju, Patrick; Chen, Yong; Lee, Whasil; Yeo, Michele; Lee, Suk Hee; Romac, Joelle; Shahid, Rafiq; ... (15 authors) (Sci Rep, 2016-06-01)
      TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this spectrum is its involvement in pain and inflammation. However, few ...

    • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. 

      Lee, Whasil; Leddy, Holly A; Chen, Yong; Lee, Suk Hee; Zelenski, Nicole A; McNulty, Amy L; Wu, Jason; ... (14 authors) (Proc Natl Acad Sci U S A, 2014-11-25)
      Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities ...

    • TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. 

      Chen, Yong; Kanju, Patrick; Fang, Quan; Lee, Suk Hee; Parekh, Puja K; Lee, Whasil; Moore, Carlene; ... (11 authors) (Pain, 2014-12)
      Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde ...