Browsing by Author "Lei, Beilei"
Now showing items 1-8 of 8
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
(PLoS One, 2014)Female sex is associated with improved outcome in experimental brain injury models, such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female gonadal steroids may be neuroprotective. ... -
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury.
(World J Crit Care Med, 2017-05-04)AIM: To address the hypothesis that young, gonad-intact female mice have improved long-term recovery associated with decreased neuroinflammation compared to male mice. METHODS: Eight to ten week-old male, female, ... -
Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.
(Journal of visualized experiments : JoVE, 2014-07-03)Intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease and is associated with significant morbidity and mortality. Lack of effective treatment and failure of large clinical trials aimed at hemostasis ... -
Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.
(Sci Rep, 2016-10-07)Presently, no pharmacological treatments have been demonstrated to improve long-term functional outcomes following intracerebral hemorrhage (ICH). Clinical evidence associates apolipoprotein E (apoE) genotype with ICH incidence ... -
Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.
(Neuroendocrinology, 2016-01)<h4>Background</h4>Preclinical evidence suggests that progesterone improves recovery after intracerebral hemorrhage (ICH); however, gonadal hormones have sex-specific effects. Therefore, an experimental model of ICH was ... -
Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.
(J Neuroinflammation, 2013-08-20)BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling ... -
Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.
(Anesthesiology, 2012-12)<h4>Background</h4>Xenon has been proven to be neuroprotective in experimental brain injury. The authors hypothesized that xenon would improve outcome from focal cerebral ischemia with a delayed treatment onset and prolonged ...
