Browsing by Author "Lennemann, Nicholas J"
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ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
Shu, Qian; Lennemann, Nicholas J; Sarkar, Saumendra N; Sadovsky, Yoel; Coyne, Carolyn B (PLoS pathogens, 2015-09-15)Interferon stimulated genes (ISGs) target viruses at various stages of their infectious life cycles, including at the earliest stage of viral entry. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) ... -
Catch me if you can: the link between autophagy and viruses.
Lennemann, Nicholas J; Coyne, Carolyn B (PLoS pathogens, 2015-03-26) -
Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.
Bayer, Avraham; Lennemann, Nicholas J; Ouyang, Yingshi; Sadovsky, Elena; Sheridan, Megan A; Roberts, R Michael; Coyne, Carolyn B; ... (8 authors) (Placenta, 2018-01)INTRODUCTION:Cultured primary human trophoblasts (PHT), derived from term placentas, are relatively resistant to infection by diverse viruses. The resistance can be conferred to non-trophoblastic cells by pre-exposing them ... -
Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.
Lennemann, Nicholas J; Evans, Azia S; Coyne, Carolyn B (Viruses, 2020-09-25)Enteroviruses manipulate host membranes to form replication organelles, which concentrate viral and host factors to allow for efficient replication. However, this process has not been well-studied in living cells throughout ...