Now showing items 1-2 of 2

    • Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. 

      Zhang, Jiming; Li, Sheng; Zhang, Dehui; Wang, Hua; Whorton, A Richard; Xian, Ming (Org Lett, 2010-09-17)
      A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, ...
    • Visualization of arrestin recruitment by a G-protein-coupled receptor. 

      Shukla, Arun K; Westfield, Gerwin H; Xiao, Kunhong; Reis, Rosana I; Huang, Li-Yin; Tripathi-Shukla, Prachi; Qian, Jiang; ... (29 authors) (Nature, 2014-08-14)
      G-protein-coupled receptors (GPCRs) are critically regulated by β-arrestins, which not only desensitize G-protein signalling but also initiate a G-protein-independent wave of signalling. A recent surge of structural data ...