Browsing by Author "Limkakeng, Alexander T"
Now showing items 1-20 of 45
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A hypothetical implementation of 'Termination of Resuscitation' protocol for out-of-hospital cardiac arrest.
Nazeha, Nuraini; Ong, Marcus Eng Hock; Limkakeng, Alexander T; Ye, Jinny J; Joiner, Anjni Patel; Blewer, Audrey; Shahidah, Nur; ... (10 authors) (Resuscitation plus, 2021-06)<h4>Background</h4>Out-of-hospital cardiac arrests with negligible chance of survival are routinely transported to hospital and many are pronounced dead thereafter. This leads to some potentially avoidable costs. The 'Termination ... -
Acute myocardial infarction in sub-Saharan Africa: the need for data.
Hertz, Julian T; Reardon, Joseph M; Rodrigues, Clarissa G; de Andrade, Luciano; Limkakeng, Alexander T; Bloomfield, Gerald S; Lynch, Catherine A (PloS one, 2014-01)BACKGROUND: Trends in the prevalence of acute myocardial infarction in sub-Saharan Africa have not been well described, despite growing recognition of the increasing burden of cardiovascular disease in low- and middle-income ... -
Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.
Hertz, Julian T; Sakita, Francis M; Kweka, Godfrey L; Limkakeng, Alexander T; Galson, Sophie W; Ye, Jinny J; Tarimo, Tumsifu G; ... (13 authors) (American heart journal, 2020-08)BACKGROUND:Growing evidence suggests that under-diagnosis of acute myocardial infarction (AMI) may be common in sub-Saharan Africa. Prospective studies of routine AMI screening among patients presenting to emergency departments ... -
Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay.
Fitzgerald, Robert L; Hollander, Judd E; Peacock, W Frank; Limkakeng, Alexander T; Breitenbeck, Nancy; Blechschmidt, Kareen; Laimighofer, Michael; ... (8 authors) (Clinica chimica acta; international journal of clinical chemistry, 2019-08)BACKGROUND:We report the analytical performance of the Elecsys® Troponin T Gen 5 STAT (TnT Gen 5 STAT; Roche Diagnostics) assay. METHODS:Measuring limits/ranges were determined in lithium-heparin plasma samples per Clinical ... -
Are patients with longer emergency department wait times less likely to consent to research?
Limkakeng, Alexander T; Glickman, Seth W; Shofer, Frances; Mani, Giselle; Drake, Weiying; Freeman, Debbie; Ascher, Simon; ... (9 authors) (Acad Emerg Med, 2012-04)OBJECTIVES: There are unique challenges to enrolling patients in emergency department (ED) clinical research studies, including the time-sensitive nature of emergency conditions, the acute care environment, and the lack ... -
Are Well-Informed Potential Trial Participants More Likely to Participate?
de Oliveira, Lucas Lentini Herling; Vissoci, Joao Ricardo Nickenig; Machado, Wagner de Lara; Rodrigues, Clarissa G; Limkakeng, Alexander T (Journal of empirical research on human research ethics : JERHRE, 2017-12)Bearing in mind the importance of the informed consent, flaws in this process may be a barrier to participants' recruitment. Our objective was to determine the relationship between the degree of comprehension of the informed ... -
Association of a Network of Immunologic Response and Clinical Features With the Functional Recovery From Crotalinae Snakebite Envenoming.
Gerardo, Charles J; Silvius, Elizabeth; Schobel, Seth; Eppensteiner, John C; McGowan, Lauren M; Elster, Eric A; Kirk, Allan D; ... (8 authors) (Frontiers in immunology, 2021-01)<h4>Background</h4>The immunologic pathways activated during snakebite envenoming (SBE) are poorly described, and their association with recovery is unclear. The immunologic response in SBE could inform a prognostic model ... -
Care of the Patient with Chest Pain in the Observation Unit.
Borawski, Joseph B; Graff, Louis G; Limkakeng, Alexander T (Emergency medicine clinics of North America, 2017-08)Care of the patient presenting to an emergency department (ED) with chest pain remains a common yet challenging aspect of emergency medicine. Acute coronary syndrome presents in nonspecific fashion. The development and evolution ... -
Direct vs Video Laryngoscopy for Difficult Airway Patients in the Emergency Department: A National Emergency Airway Registry Study.
Ruderman, Brandon T; Mali, Martina; Kaji, Amy H; Kilgo, Robert; Watts, Susan; Wells, Radosveta; Limkakeng, Alexander T; ... (12 authors) (The western journal of emergency medicine, 2022-08)<h4>Introduction</h4>Previous studies suggest improved intubation success using video laryngoscopy (VL) vs direct laryngoscopy (DL), yet recent randomized trials have not shown clear benefit of one method over the other. ... -
Duplicated or Ectopic Renal Collecting System in Two Adult Emergency Department Patients.
Theophanous, Rebecca G; Limkakeng, Alexander T; Broder, Joshua S (The Journal of emergency medicine, 2019-12-04)BACKGROUND:Duplicated renal collecting system is a urological anomaly often found in pediatric patients. It is less commonly diagnosed in adulthood, particularly in a pregnant patient. Many point-of-care ultrasonography ... -
Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome.
Peacock, W Frank; Baumann, Brigette M; Bruton, Deborah; Davis, Thomas E; Handy, Beverly; Jones, Christopher W; Hollander, Judd E; ... (12 authors) (JAMA cardiology, 2018-02)Importance:Physicians need information on how to use the first available high-sensitivity troponin (hsTnT) assay in the United States to identify patients at very low risk for 30-day adverse cardiac events (ACE). Objective:To ... -
Evaluation of T-Wave Morphology in Patients With Left Bundle Branch Block and Suspected Acute Coronary Syndrome.
Meyers, H Pendell; Jaffa, Elias; Smith, Stephen W; Drake, Weiying; Limkakeng, Alexander T (The Journal of emergency medicine, 2016-09)T-wave morphology in the setting of left bundle branch block (LBBB) has been proposed as an indicator of myocardial ischemia.We sought to identify T-wave morphology findings in patients with LBBB that predict non-ST-segment ... -
Heart failure care and outcomes in a Tanzanian emergency department: A prospective observational study.
Prattipati, Sainikitha; Sakita, Francis M; Kweka, Godfrey L; Tarimo, Tumsifu G; Peterson, Timothy; Mmbaga, Blandina T; Thielman, Nathan M; ... (10 authors) (PloS one, 2021-01)<h4>Background</h4>The burden of heart failure is growing in sub-Saharan Africa, but there is a dearth of data characterizing care and outcomes of heart failure patients in the region, particularly in emergency department ... -
Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.
Limkakeng, Alexander T; Hertz, Julian; Lerebours, Reginald; Kuchibhatla, Maragatha; McCord, James; Singer, Adam J; Apple, Fred S; ... (10 authors) (The American journal of emergency medicine, 2022-06) -
Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.
Breslin, Adam W; Limkakeng, Alexander T; Silvius, Elizabeth; Staton, Catherine A; Almond, Chandra; Joshi, Mary-Beth; Adams, Bartley; ... (11 authors) (Clinical and translational science, 2021-09)Traumatic injuries afflict more than 5 million people globally every year. Current and past animal research has demonstrated association among alcohol, trauma, and impaired immune function, whereas human registries have ... -
Impact of renal dysfunction on acute coronary syndrome evaluation in observation unit patients.
Limkakeng, Alexander T; Chandra, Abhinav (Am J Emerg Med, 2010-07)OBJECTIVES: The impact of renal disease on risk stratification of patients at low risk for potential acute coronary syndrome has not been well defined. The objective of this study was to document the prevalence of renal ... -
Implementation of the HEART Pathway: Using the Consolidated Framework for Implementation Research.
Gesell, Sabina B; Golden, Shannon L; Limkakeng, Alexander T; Carr, Christine M; Matuskowitz, Andrew; Smith, Lane M; Mahler, Simon A (Critical pathways in cardiology, 2018-12)OBJECTIVE:The HEART Pathway is an evidence-based decision tool for identifying emergency department (ED) patients with acute chest pain who are candidates for early discharge, to reduce unhelpful and potentially harmful ... -
Improving the Emergency Care Research Investigator Pipeline: SAEM/ACEP Recommendations.
Ranney, Megan L; Limkakeng, Alexander T; Carr, Brendan; Zink, Brian; Kaji, Amy H; ACEP SAEM Research Committees (approved by ACEP-SAEM Board of Directors) (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015-07) -
Incidence of Acute Myocardial Infarction in Northern Tanzania: A Modeling Approach Within a Prospective Observational Study.
Hertz, Julian T; Madut, Deng B; Rubach, Matthew P; William, Gwamaka; Crump, John A; Galson, Sophie W; Maro, Venance P; ... (12 authors) (Journal of the American Heart Association, 2021-08)Background Rigorous incidence data for acute myocardial infarction (AMI) in sub-Saharan Africa are lacking. Consequently, modeling studies based on limited data have suggested that the burden of AMI and AMI-associated mortality ... -
International, multicenter evaluation of a new D-dimer assay for the exclusion of venous thromboembolism using standard and age-adjusted cut-offs.
Parry, Blair Alden; Chang, Anna Marie; Schellong, Sebastian M; House, Stacey L; Fermann, Gregory J; Deadmon, Erin K; Giordano, Nicholas J; ... (30 authors) (Thrombosis research, 2018-04-05)We sought to determine the test characteristics of an automated INNOVANCE D-dimer assay for the exclusion of pulmonary embolism (PE) and deep venous thrombosis (DVT) in emergency department (ED) patients using standard and ...