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Browsing by Author "Liu, Hongliang"
Now showing items 1-20 of 65
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A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.
(PloS one, 2012-01-17)The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies ... -
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
(BMC cancer, 2011-01)BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported ... -
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.
(Scientific reports, 2016-10-07)Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 ... -
A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.
(Carcinogenesis, 2021-10-13)ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins ... -
APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.
(Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020-04)BACKGROUND:Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain ... -
Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease.
(Journal of Alzheimer's disease : JAD, 2021-10-13)Mild cognitive impairment (MCI) is a heterogeneous condition and MCI patients are at increased risk of progression to dementia due to Alzheimer's disease (AD). In this study, we aim to evaluate the associations between polygenic ... -
Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival.
(Annals of translational medicine, 2021-03)<h4>Background</h4>Peroxisomes are ubiquitous and dynamic organelles that are involved in the metabolism of reactive oxygen species (ROS) and lipids. However, whether genetic variants in the peroxisome pathway genes are ... -
Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.
(Molecular carcinogenesis, 2021-07)Forkhead box class O (FOXO) transcription factors play a pivotal role in regulating a variety of biological processes, including organismal development, cell signaling, cell metabolism, and tumorigenesis. Therefore, ... -
Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
(Molecular carcinogenesis, 2018-06)Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients ... -
Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.
(Scientific reports, 2017-03-17)mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in ... -
Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
(Cancer medicine, 2020-11-16)Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from ... -
Associations between smoking behavior-related alleles and the risk of melanoma.
(Oncotarget, 2016-07-26)Several studies have reported that cigarette smoking is inversely associated with the risk of melanoma. This study further tested whether incorporating genetic factors will provide another level of evaluation of mechanisms ... -
Component-wise gradient boosting and false discovery control in survival analysis with high-dimensional covariates.
(Bioinformatics, 2016-01-01)MOTIVATION: Technological advances that allow routine identification of high-dimensional risk factors have led to high demand for statistical techniques that enable full utilization of these rich sources of information for ... -
Effect of Exercise and Rehabilitation Therapy on Risk of Hospitalization in Parkinson's Disease.
(Movement disorders clinical practice, 2022-05-02)<h4>Background</h4>Exercise and physical therapy (PT) can improve motor function and quality of life in individuals with Parkinson's disease (PD), but their role in hospitalization avoidance is not well-studied.<h4>Objec... -
ERCC1 and ERCC2 variants predict survival in gastric cancer patients.
(PloS one, 2013-01)PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore, functional single nucleotide polymorphisms (SNPs) ... -
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.
(Cancer Epidemiol Biomarkers Prev, 2015-07)BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous melanoma to promote growth and aggressive metastatic potential of primary melanoma cells. Therefore, genetic variants in Notch pathway ... -
Genetic association between epigenetic aging-acceleration and the progression of mild cognitive impairment to Alzheimer's disease.
(The journals of gerontology. Series A, Biological sciences and medical sciences, 2022-07-07)Alzheimer's disease (AD) is a progressive neurodegenerative disorder and previous studies have showed its association with accelerated aging. In this study, we hypothesized that SNPs that contributed to aging acceleration ... -
Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
(International journal of cancer, 2018-11)The toll-like receptor (TLR) signaling pathway plays an important role in the innate immune responses and antigen-specific acquired immunity. Aberrant activation of the TLR pathway has a significant impact on carcinogenesis ... -
Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.
(Molecular carcinogenesis, 2022-05-03)Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but its role in development and progression of non-small cell lung cancer (NSCLC) is not well understood. Here, we investigated ... -
Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.
(International journal of cancer, 2019-02-08)Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively ...
