Now showing items 1-8 of 8

    • A translatable predictor of human radiation exposure. 

      Abedi, M; Chao, Nelson J; Chute, JP; Dressman, HK; Himburg, Heather; Lucas, J; Minor, K; ... (12 authors) (PLoS One, 2014)
      Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ...
    • ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. 

      Chi, JT; Cyr, Derek; Huang, Z; Ilkayeva, Olga; Keenan, MM; Kim, So Young; Liu, B; ... (14 authors) (PLoS Genet, 2015-10)
      In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell ...
    • Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies. 

      Carin, Lawrence; Chen, B; Chen, M; Dunson, David B; Ginsburg, Geoffrey Steven; Hero, Alfred; Lucas, J; ... (10 authors) (BMC Bioinformatics, 2010-11-09)
      BACKGROUND: Nonparametric Bayesian techniques have been developed recently to extend the sophistication of factor models, allowing one to infer the number of appropriate factors from the observed data. We consider such techniques ...
    • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 

      Chao, Nelson J; Chute, JP; Daher, P; Doan, Phuong Linh; Dressman, HK; Himburg, Heather; Lucas, J; ... (10 authors) (PLoS One, 2010-07-12)
      In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
    • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 

      Ahn, SH; Cyr, Derek; Deshmukh, H; Fowler, Vance Garrison Jr; Lucas, J; Rude, Thomas H; Scott, WK; ... (13 authors) (PLoS Pathog, 2014-06)
      Using A/J mice, which are susceptible to Staphylococcus aureus, we sought to identify genetic determinants of susceptibility to S. aureus, and evaluate their function with regard to S. aureus infection. One QTL region on ...
    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

      Ahn, SH; Cairns, CB; Cyr, Derek; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Kingsmore, Stephen F; ... (17 authors) (PLoS One, 2013)
      Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
    • Host gene expression classifiers diagnose acute respiratory illness etiology. 

      Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)
      Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
    • Researcher practices on returning genetic research results. 

      Haga, Susanne B; Heaney, C; Lucas, J; Tindall, G (Genet Test Mol Biomarkers, 2010-12)
      BACKGROUND/AIMS: as genetic and genomic research proliferates, debate has ensued about returning results to participants. In addition to consideration of the benefits and harms to participants, researchers must also consider ...