Browsing by Author "Lucas, Joseph"
Now showing items 1-7 of 7
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A translatable predictor of human radiation exposure.
(PLoS One, 2014)Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ... -
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
(PLoS Genet, 2015-10)In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell ... -
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies
(BMC BIOINFORMATICS, 2010-11-09) -
Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles.
(PLoS One, 2010-07-12)In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ... -
Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.
(PLoS Pathog, 2014-06)Using A/J mice, which are susceptible to Staphylococcus aureus, we sought to identify genetic determinants of susceptibility to S. aureus, and evaluate their function with regard to S. aureus infection. One QTL region on ... -
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ... -
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
