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Browsing by Author "Luo, Sheng"
Now showing items 1-20 of 116
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A Bayesian approach for individual-level drug benefit-risk assessment.
(Statistics in medicine, 2019-07)In existing benefit-risk assessment (BRA) methods, benefit and risk criteria are usually identified and defined separately based on aggregated clinical data and therefore ignore the individual-level differences as well as ... -
A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.
(Carcinogenesis, 2021-10-13)ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins ... -
A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.
(Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018-05)INTRODUCTION:Characterizing progression in Alzheimer's disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, ... -
Adjuvant Chemotherapy Versus Observation Following Resection for Patients With Nonmetastatic Poorly Differentiated Colorectal Neuroendocrine Carcinomas.
(Annals of surgery, 2019-08-30)OBJECTIVE:The aim of this study was to determine whether adjuvant chemotherapy (AC) provides a survival benefit in patients with nonmetastatic poorly differentiated colorectal neuroendocrine carcinomas (CRNECs) following ... -
Adverse Events of Immune Checkpoint Inhibitor-Based Therapies for Unresectable Hepatocellular Carcinoma in Prospective Clinical Trials: A Systematic Review and Meta-analysis
<jats:p>Introduction: To investigate the incidence and spectrum of adverse events in unresectable hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICIs) or ICI-based combinations. Methods: ... -
Analysis of antepartum obstetric triage utilization at 24 weeks and beyond
(AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021-02) -
APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.
(Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020-04)BACKGROUND:Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain ... -
Application of Longitudinal Item Response Theory Models to Modeling Parkinson's Disease Progression.
(CPT: pharmacometrics & systems pharmacology, 2022-07-27)The Movement Disorder Society revised version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts 2 and 3 reflect patient-reported functional impact and clinician-reported severity of motor signs of Parkinson's ... -
Association and Trends in Medicare Denials and Utilization for Brain CT: Indirect Impacts by Targeted Policy Intervention?
(Current problems in diagnostic radiology, 2022-07-30)Twenty-five years of annual Medicare Physician/Supplier Procedure Summary (PSPS) Master File data were used to assess trends in normalized volume and claim denial rates for brain computerized tomography. Alongside growth ... -
Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease.
(Journal of Alzheimer's disease : JAD, 2021-10-13)Mild cognitive impairment (MCI) is a heterogeneous condition and MCI patients are at increased risk of progression to dementia due to Alzheimer's disease (AD). In this study, we aim to evaluate the associations between polygenic ... -
Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival.
(Annals of translational medicine, 2021-03)<h4>Background</h4>Peroxisomes are ubiquitous and dynamic organelles that are involved in the metabolism of reactive oxygen species (ROS) and lipids. However, whether genetic variants in the peroxisome pathway genes are ... -
Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.
(Molecular carcinogenesis, 2021-07)Forkhead box class O (FOXO) transcription factors play a pivotal role in regulating a variety of biological processes, including organismal development, cell signaling, cell metabolism, and tumorigenesis. Therefore, ... -
Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
(Cancer medicine, 2020-11-16)Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from ... -
Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk.
(American journal of cancer research, 2020-01)The ATM serine/threonine kinase (ATM) pathway plays important roles in pancreatic cancer (PanC) development and progression, but the roles of genetic variants of the genes in this pathway in the etiology of PanC are unknown. ... -
Automated Structured Reporting for Thyroid Ultrasound: Effect on Reporting Errors and Efficiency.
(Journal of the American College of Radiology : JACR, 2020-08-17)PURPOSE:To compare the effectiveness of different reporting templates using the ACR Thyroid Imaging Reporting and Data System (TI-RADS) for thyroid ultrasound. METHODS:In this retrospective study, four radiologists implemented ... -
Bayesian Functional Joint Models for Multivariate Longitudinal and Time-to-Event Data.
(Computational statistics & data analysis, 2019-01)A multivariate functional joint model framework is proposed which enables the repeatedly measured functional outcomes, scalar outcomes, and survival process to be modeled simultaneously while accounting for association among ... -
Bayesian inference and dynamic prediction for multivariate longitudinal and survival data
(The Annals of Applied Statistics, 2023-09-01) -
Bayesian inference and dynamic prediction of multivariate joint model with functional data: An application to Alzheimer's disease.
(Statistics in medicine, 2021-10-14)Alzheimer's disease (AD) is a severe neurodegenerative disorder impairing multiple domains, for example, cognition and behavior. Assessing the risk of AD progression and initiating timely interventions at early stages are ... -
Bayesian quantile regression joint models: Inference and dynamic predictions.
(Statistical methods in medical research, 2018-01)In the traditional joint models of a longitudinal and time-to-event outcome, a linear mixed model assuming normal random errors is used to model the longitudinal process. However, in many circumstances, the normality assumption ...
