Now showing items 1-2 of 2

    • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 

      Boyce, Michael; Bryant, Kevin F; Jousse, Céline; Long, Kai; Harding, Heather P; Scheuner, Donalyn; Kaufman, Randal J; ... (11 authors) (Science (New York, N.Y.), 2005-02)
      Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect ...
    • Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. 

      Long, Kai; Boyce, Michael; Lin, He; Yuan, Junying; Ma, Dawei (Bioorganic & medicinal chemistry letters, 2005-09)
      The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl ...