Browsing by Author "Madden, David J"
Now showing items 1-20 of 31
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Adult age differences in functional connectivity during executive control.
(Neuroimage, 2010-08-15)Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task ... -
Age mediation of frontoparietal activation during visual feature search.
(Neuroimage, 2014-11-15)Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature ... -
Age-related differences in resolving semantic and phonological competition during receptive language tasks.
(Neuropsychologia, 2016-12)Receptive language (e.g., reading) is largely preserved in the aging brain, and semantic processes in particular may continue to develop throughout the lifespan. We investigated the neural underpinnings of phonological and ... -
Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
(Cognitive, affective & behavioral neuroscience, 2019-08)As we age we have increasing difficulty with phonological aspects of language production. Yet semantic processes are largely stable across the life span. This suggests a fundamental difference in the cognitive and potentially ... -
Age-related differences in the neural bases of phonological and semantic processes.
(Journal of cognitive neuroscience, 2014-12)Changes in language functions during normal aging are greater for phonological compared with semantic processes. To investigate the behavioral and neural basis for these age-related differences, we used fMRI to examine younger ... -
Age-related preservation of top-down control over distraction in visual search.
(Experimental aging research, 2010-07)Visual search studies have demonstrated that older adults can have preserved or even increased top-down control over distraction. However, the results are mixed as to the extent of this age-related preservation. The present ... -
Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults.
(Neuroimage, 2015-01-15)In the human brain, iron is more prevalent in gray matter than in white matter, and deep gray matter structures, particularly the globus pallidus, putamen, caudate nucleus, substantia nigra, red nucleus, and dentate nucleus, ... -
Cerebral white matter connectivity, cognition, and age-related macular degeneration.
(NeuroImage. Clinical, 2021-02-23)Age-related macular degeneration (AMD) is a common retina disease associated with cognitive impairment in older adults. The mechanism(s) that account for the link between AMD and cognitive decline remain unclear. Here we ... -
Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.
(Anesthesiology, 2016-08)BACKGROUND: Limited information exists on the effects of temporary functional deafferentation (TFD) on brain activity after peripheral nerve block (PNB) in healthy humans. Increasingly, resting-state functional connectivity ... -
Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.
(Journal of neurovirology, 2017-06)This study investigated the association of HIV infection and cocaine dependence with cerebral white matter integrity using diffusion tensor imaging (DTI). One hundred thirty-five participants stratified by HIV and cocaine ... -
Cognitive and neural contributors to emotion regulation in aging.
(Social cognitive and affective neuroscience, 2011-04)Older adults, compared to younger adults, focus on emotional well-being. While the lifespan trajectory of emotional processing and its regulation has been characterized behaviorally, few studies have investigated the underlying ... -
Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.
(Biochimica et biophysica acta, 2012-03)In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses ... -
Effects of adult age and blood pressure on executive function and speed of processing.
(Experimental aging research, 2010-04)Previous research has established that the effects of chronically increased blood pressure (BP) on cognition interact with adult age, but the relevant cognitive processes are not well defined. In this cross-sectional study, ... -
Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age.
(Hum Brain Mapp, 2017-04)We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional ... -
Functional brain connectivity and cognition: effects of adult age and task demands.
(Neurobiology of aging, 2013-08)Previous neuroimaging research has documented that patterns of intrinsic (resting state) functional connectivity (FC) among brain regions covary with individual measures of cognitive performance. Here, we examined the relation ... -
Functional modular architecture underlying attentional control in aging.
(NeuroImage, 2017-07)Previous research suggests that age-related differences in attention reflect the interaction of top-down and bottom-up processes, but the cognitive and neural mechanisms underlying this interaction remain an active area ... -
Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed.
(Brain structure & function, 2015-09)Although age-related differences in white matter have been well documented, the degree to which regional, tract-specific effects can be distinguished from global, brain-general effects is not yet clear. Similarly, the manner ... -
Influence of encoding difficulty, word frequency, and phonological regularity on age differences in word naming.
(Experimental aging research, 2011-05)It is presently unclear as to why older adults take longer than younger adults to recognize visually presented words. To examine this issue in more detail, the authors conducted two word-naming studies (Experiment 1: 20 ... -
Influence of structural and functional brain connectivity on age-related differences in fluid cognition.
(Neurobiology of aging, 2020-12)We used graph theoretical measures to investigate the hypothesis that structural brain connectivity constrains the influence of functional connectivity on the relation between age and fluid cognition. Across 143 healthy, ... -
Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere.
(Neurobiol Aging, 2017-11-14)Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive ...
