Browsing by Author "Manandhar, Dinesh"

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HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells.

Frank, Christopher L; Manandhar, Dinesh; Gordân, Raluca; Crawford, Gregory E (Epigenetics Chromatin, 2016)

BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. However, clinical use is often confounded by toxicity, perhaps due to indiscriminate ...
Methods for Comparative Analysis of Chromatin Accessibility and Gene Expression, With Applications to Cellular Reprogramming

Manandhar, Dinesh (2018)

Cellular reprogramming processes remain poorly characterized at the level of genome- wide chromatin and gene expression changes. Specifically, the extent to which re- programmed cells differ quantitatively from both the ...