Browsing by Author "Mardis, Elaine R"

Now showing items 1-5 of 5

    • A high-resolution map of human evolutionary constraint using 29 mammals. 

      Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F; Parker, Brian J; Washietl, Stefan; Kheradpour, Pouya; ... (89 authors) (Nature, 2011-10-12)
      The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome ...

    • Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. 

      Leung, Wilson; Shaffer, Christopher D; Reed, Laura K; Smith, Sheryl T; Barshop, William; Dirkes, William; Dothager, Matthew; ... (1014 authors) (G3 (Bethesda, Md.), 2015-03-04)
      The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution ...

    • High early death rates, treatment resistance, and short survival of Black adolescents and young adults with AML. 

      Larkin, Karilyn T; Nicolet, Deedra; Kelly, Benjamin J; Mrózek, Krzysztof; LaHaye, Stephanie; Miller, Katherine E; Wijeratne, Saranga; ... (30 authors) (Blood advances, 2022-10)
      Survival of patients with acute myeloid leukemia (AML) is inversely associated with age, but the impact of race on outcomes of adolescent and young adult (AYA; range, 18-39 years) patients is unknown. We compared survival ...

    • Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element. 

      Leung, Wilson; Shaffer, Christopher D; Chen, Elizabeth J; Quisenberry, Thomas J; Ko, Kevin; Braverman, John M; Giarla, Thomas C; ... (276 authors) (G3 (Bethesda, Md.), 2017-08-07)
      The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it ...

    • The genome of a songbird. 

      Warren, Wesley C; Clayton, David F; Ellegren, Hans; Arnold, Arthur P; Hillier, Ladeana W; Künstner, Axel; Searle, Steve; ... (82 authors) (Nature, 2010-04-01)
      The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented ...