Now showing items 1-5 of 5

    • Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. 

      Anders, Carey K; Acharya, Chaitanya R; Hsu, David S; Broadwater, Gloria; Garman, Katherine; Foekens, John A; Zhang, Yi; ... (14 authors) (PLoS One, 2008-01-02)
      PURPOSE: To define the biology driving the aggressive nature of breast cancer arising in young women. EXPERIMENTAL DESIGN: Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts ...
    • Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. 

      Schildkraut, Joellen M; Iversen, Edwin S; Wilson, Melanie A; Clyde, Merlise A; Moorman, Patricia G; Palmieri, Rachel T; Whitaker, Regina; ... (10 authors) (PLoS One, 2010-04-08)
      BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
    • Expression signatures of TP53 mutations in serous ovarian cancers. 

      Bernardini, Marcus Q; Baba, Tsukasa; Lee, Paula S; Barnett, Jason C; Sfakianos, Gregory P; Secord, Angeles Alvarez; Murphy, Susan K; ... (10 authors) (BMC Cancer, 2010-05-26)
      BACKGROUND: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology ...
    • Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. 

      Chen, Po-Han; Smith, Timothy J; Wu, Jianli; Siesser, Priscila F; Bisnett, Brittany J; Khan, Farhan; Hogue, Maxwell; ... (14 authors) (The EMBO journal, 2017-08)
      O-GlcNAcylation is an essential, nutrient-sensitive post-translational modification, but its biochemical and phenotypic effects remain incompletely understood. To address this question, we investigated the global transcriptional ...
    • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 

      Bennett, Craig B; Westmoreland, Tammy J; Verrier, Carmel S; Blanchette, Carrie AB; Sabin, Tiffany L; Phatnani, Hemali P; Mishina, Yuliya V; ... (16 authors) (PLoS One, 2008-01-16)
      BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved ...