Browsing by Author "Mata, Brian A"
Now showing items 1-5 of 5
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Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.
(Open Orthop J, 2012)Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, and even midbrain, ... -
Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist.
(J Orthop Res, 2011-05)Interleukin-1 beta (IL1β) is a proinflammatory cytokine that mediates arthritic pathologies. Our objectives were to evaluate pain and limb dysfunction resulting from IL1β over-expression in the rat knee and to investigate ... -
In Vivo luminescent imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.
(Arthritis Rheum, 2013-11-18)Objective: To investigate the relationship between NF-κB activity, cytokine levels, and pain sensitivities in a rodent model of osteoarthritis (OA). Method: OA was induced in transgenic NF-κB luciferase reporter mice via ... -
Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism.
(Arthritis research & therapy, 2011-08-26)Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagonists can attenuate ... -
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both preclinical OA models and OA patients. ...
