Browsing by Author "Mathew, Joseph P"
Now showing items 1-20 of 26
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Association of Brain Injury Biomarkers and Circulatory Shock Following Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.
(Journal of neurosurgical anesthesiology, 2021-12)<h4>Introduction</h4>Early circulatory shock following traumatic brain injury (TBI) is a multifactorial process; however, the impact of brain injury biomarkers on the risk of shock has not been evaluated. We examined the ... -
Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.
(Journal of Alzheimer's disease : JAD, 2021-02-26)<h4>Background</h4>Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized ... -
Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.
(BMJ Open, 2013-09-20)INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to ... -
Echocardiogram Utilization Patterns and Association With Mortality Following Severe Traumatic Brain Injury
(Anesthesia & Analgesia, 2020-08-12) -
Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.
(Anesthesia and analgesia, 2019-05-03)Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before ... -
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following ... -
Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.
(BMJ Open, 2015-05-06)OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions ... -
Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.
(Scientific reports, 2021-02-04)Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative ... -
Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.
(Front Syst Neurosci, 2017)Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality ... -
Longitudinal Changes in Regional Cerebral Perfusion and Cognition Following Cardiac Surgery.
(The Annals of thoracic surgery, 2018-09-22)Cardiac surgery has been associated with increased risk of postoperative cognitive decline, as well as dementia risk in the general population. Few studies, however, have examined the impact of coronary revascularization ... -
Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.
(J Thorac Cardiovasc Surg, 2017-01)OBJECTIVE: Aortic surgeries requiring hypothermic circulatory arrest evoke systemic inflammatory responses that often manifest as vasoplegia and hypotension. Because mast cells can rapidly release vasoactive and proinflammatory ... -
Neurological injury after transcatheter aortic valve implantation: are the trees falling silently or is our hearing impaired?
(Circ Cardiovasc Interv, 2013-12) -
Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study
(British Journal of Anaesthesia, 2021-09) -
Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.
(Anesthesiology, 2016-02)BACKGROUND: Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the ... -
Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.
(Annals of clinical and translational neurology, 2022-02)<h4>Objective</h4>Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship ... -
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality has been challenged. The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ... -
Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.
(J Am Geriatr Soc, 2017-01)OBJECTIVES: To look for changes in intrinsic functional brain connectivity associated with postoperative changes in cognition, a common complication in seniors undergoing major surgery, using resting-state functional magnetic ... -
Sparcl1/Hevin drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
(JCI insight, 2022-10)Hevin/Sparcl1 is an astrocyte-secreted protein and regulates synapse formation. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared to wild-type mice, hevin-null mice ... -
Stellate Ganglion Blockade: an Intervention for the Management of Ventricular Arrhythmias.
(Current hypertension reports, 2020-10-23)PURPOSE OF REVIEW:To highlight the indications, procedural considerations, and data supporting the use of stellate ganglion blockade (SGB) for management of refractory ventricular arrhythmias. RECENT FINDINGS:In patients ... -
Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.
(Hum Brain Mapp, 2017-11-21)OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative ...
