Browsing by Author "McCarthy, Gregory"
Now showing items 1-13 of 13
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Acute effects of trauma-focused research procedures on participant safety and distress
(Psychiatry Research, 2014-01-30)The ethical conduct of research on posttraumatic stress disorder (PTSD) requires assessing the risks to study participants. Some previous findings suggest that patients with PTSD report higher distress compared to non-PTSD ... -
Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.
(Neuropsychopharmacology, 2014-01)The amygdala is a major structure that orchestrates defensive reactions to environmental threats and is implicated in hypervigilance and symptoms of heightened arousal in posttraumatic stress disorder (PTSD). The basolateral ... -
Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.
(Arch Gen Psychiatry, 2012-11)CONTEXT: Smaller hippocampal volumes are well established in posttraumatic stress disorder (PTSD), but the relatively few studies of amygdala volume in PTSD have produced equivocal results. OBJECTIVE: To assess a large cohort ... -
Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction.
(Biol Psychiatry, 2015-02-15)BACKGROUND: Anxiety produced by environmental threats can impair goal-directed processing and is associated with a range of psychiatric disorders, particularly when aversive events occur unpredictably. The prefrontal cortex ... -
Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.
(Human Brain Mapping, 2013-11)Mild traumatic brain injury (TBI) is a common source of morbidity from the wars in Iraq and Afghanistan. With no overt lesions on structural MRI, diagnosis of chronic mild TBI in military veterans relies on obtaining an ... -
Emotion-attention network interactions during a visual oddball task.
(Brain Res Cogn Brain Res, 2004-06)Emotional and attentional functions are known to be distributed along ventral and dorsal networks in the brain, respectively. However, the interactions between these systems remain to be specified. The present study used ... -
Faces evoke spatially differentiated patterns of BOLD activation and deactivation.
(Neuroreport, 2003-05-23)Using fMRI techniques sensitive to blood oxygen-level dependent (BOLD) contrast, we measured brain activity in participants (n=8) as they viewed images of faces presented periodically within a continuously changing montage ... -
Neural systems for guilt from actions affecting self versus others.
(Neuroimage, 2012-03)Guilt is a core emotion governing social behavior by promoting compliance with social norms or self-imposed standards. The goal of this study was to contrast guilty responses to actions that affect self versus others, since ... -
Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD.
(J Psychiatr Res, 2011-05)Neurobiological models of posttraumatic stress disorder (PTSD) suggest that altered activity in the medial temporal lobes (MTL) during encoding of traumatic memories contribute to the development and maintenance of the disorder. ... -
Scan-rescan reliability of subcortical brain volumes derived from automated segmentation.
(Hum Brain Mapp, 2010-11)Large-scale longitudinal studies of regional brain volume require reliable quantification using automated segmentation and labeling. However, repeated MR scanning of the same subject, even if using the same scanner ... -
Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder.
(BMC Psychiatry, 2011-05-05)BACKGROUND: Serotonergic system dysfunction has been implicated in posttraumatic stress disorder (PTSD). Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion ... -
Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.
(Front Hum Neurosci, 2010)During times of emotional stress, individuals often engage in emotion regulation to reduce the experiential and physiological impact of negative emotions. Interestingly, emotion regulation strategies also influence memory ... -
When strangers pass: processing of mutual and averted social gaze in the superior temporal sulcus.
(Psychol Sci, 2004-09)Using functional magnetic resonance imaging (fMRI), we investigated brain activity evoked by mutual and averted gaze in a compelling and commonly experienced social encounter. Through virtual-reality goggles, subjects viewed ...
