Browsing by Author "McGue, Matt"

Cohort Profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies - secular trends in the health and functioning of the very old.

Rasmussen, Signe Høi; Andersen-Ranberg, Karen; Thinggaard, Mikael; Jeune, Bernard; Skytthe, Axel; Christiansen, Lene; Vaupel, James W; ... (9 authors) (Int J Epidemiol, 2017-04-22)

DNA methylation age is associated with mortality in a longitudinal Danish twin study.

Christiansen, Lene; Lenart, Adam; Tan, Qihua; Vaupel, James W; Aviv, Abraham; McGue, Matt; Christensen, Kaare (Aging Cell, 2016-02)

An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, ...

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen, Mette; Dato, Serena; Tan, Qihua; Thinggaard, Mikael; Kleindorp, Rabea; Beekman, Marian; Suchiman, H Eka D; ... (19 authors) (Age (Dordr), 2013-04)

In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; ...

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.

van den Berg, Stéphanie M; de Moor, Marleen HM; McGue, Matt; Pettersson, Erik; Terracciano, Antonio; Verweij, Karin JH; Amin, Najaf; ... (88 authors) (Behavior genetics, 2014-07)

Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, ...

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen, Mette; Dato, Serena; Tan, Qihua; Thinggaard, Mikael; Kleindorp, Rabea; Beekman, Marian; Jacobsen, Rune; ... (19 authors) (Exp Gerontol, 2012-05)

Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging ...

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

Pedersen, Jacob K; Skytthe, Axel; McGue, Matt; Honig, Lawrence S; Franceschi, Claudio; Kirkwood, Thomas BL; Passarino, Giuseppe; ... (10 authors) (Ann Epidemiol, 2015-08)

PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific ...

Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart.

Christensen, Kaare; Thinggaard, Mikael; Oksuzyan, Anna; Steenstrup, Troels; Andersen-Ranberg, Karen; Jeune, Bernard; McGue, Matt; ... (8 authors) (Lancet, 2013-11-02)

BACKGROUND: A rapidly increasing proportion of people in high-income countries are surviving into their tenth decade. Concern is widespread that the basis for this development is the survival of frail and disabled elderly ...