Now showing items 1-5 of 5

    • Aggregate complexes of HIV-1 induced by multimeric antibodies. 

      Denny, Thomas Norton; Ferrari, Guido; Haynes, Barton Ford; Hwang, KK; Kaewkungwal, J; Kim, JH; King, DF; ... (19 authors) (Retrovirology, 2014-10-02)
      BACKGROUND: Antibody mediated viral aggregation may impede viral transfer across mucosal surfaces by hindering viral movement in mucus, preventing transcytosis, or reducing inter-cellular penetration of epithelia thereby ...
    • Host determinants of HIV-1 control in African Americans. 

      Carrington, Mary; Cronin, KD; Fellay, J; Gao, X; Ge, Dongliang; Goldstein, David Benjamin; Gumbs, Curtis E; ... (16 authors) (J Infect Dis, 2010-04-15)
      We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
    • Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. 

      Alam, S Munir; Blair, Lily M; Chao, A; Cocklin, SL; Dennison, SM; Duffy, R; Evans, A; ... (46 authors) (PLoS Pathog, 2015-08)
      HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies ...
    • Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. 

      Alam, S Munir; Bonsignori, Mattia; Denny, Thomas Norton; Ferrari, Guido; Fong, Y; Gilbert, P; Haynes, Barton Ford; ... (24 authors) (J Virol, 2013-07)
      The detailed examination of the antibody repertoire from RV144 provides a unique template for understanding potentially protective antibody functions. Some potential immune correlates of protection were untested in the correlates ...
    • Influence of HLA-C expression level on HIV control. 

      Apps, R; Bosch, R; Brumme, CJ; Brumme, ZL; Buchbinder, S; Carlson, JM; Carrington, Mary; ... (37 authors) (Science, 2013-04-05)
      A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized ...