Browsing by Author "Moseley, M Arthur"
Now showing items 1-18 of 18
-
A comparative analysis of egg provisioning using mass spectrometry during rapid life history evolution in sea urchins.
(Evolution & development, 2019-05-17)A dramatic life history switch that has evolved numerous times in marine invertebrates is the transition from planktotrophic (feeding) to lecithotrophic (nonfeeding) larval development-an evolutionary tradeoff with many ... -
A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA.
(Journal of molecular biology, 2014-05)Bacteria respond to adverse environmental conditions by switching on the expression of large numbers of genes that enable them to adapt to unfavorable circumstances. In Bacillus subtilis, many adaptive genes are under the ... -
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.
(Translational psychiatry, 2021-03-02)Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. ... -
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
(Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018-10-08)INTRODUCTION:Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism ... -
Calcineurin Targets Involved in Stress Survival and Fungal Virulence.
(PLoS Pathog, 2016-09)Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels caused by stress, and transduces signals ... -
Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.
(Journal of the American Society for Mass Spectrometry, 2021-05-24)Immune-based metabolic reprogramming of arginine utilization in the brain contributes to the neuronal pathology associated with Alzheimer's disease (AD). To enable our long-term goals of differentiation of AD mouse model ... -
Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.
(Journal of Alzheimer's disease : JAD, 2021-02-26)<h4>Background</h4>Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized ... -
Convergent transcriptional specializations in the brains of humans and song-learning birds.
(Science, 2014-12-12)Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes ... -
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees.
(Genome Biol Evol, 2015-07-10)Although transcriptomic profiling has become the standard approach for exploring molecular differences in the primate brain, very little is known about how the expression levels of gene transcripts relate to downstream protein ... -
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.
(Scientific reports, 2016-09-27)On Earth, biological systems have evolved in response to environmental stressors, interactions dictated by physical forces that include gravity. The absence of gravity is an extreme stressor and the impact of its absence ... -
Microproteomics: quantitative proteomic profiling of small numbers of laser-captured cells.
(Cold Spring Harb Protoc, 2011-02-01) -
Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.
(EBioMedicine, 2017-03)Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects ... -
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
(PLoS One, 2014)The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development ... -
Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation.
(Clin Proteomics, 2013-01-03)UNLABELLED: BACKGROUND: In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood ... -
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
(Stroke, 2014-04)<h4>Background and purpose</h4>Small ubiquitin-like modifier (SUMO) conjugation is a post-translational modification associated with many human diseases. Characterization of the SUMO-modified proteome is pivotal to define ... -
Structure and DNA-binding traits of the transition state regulator AbrB.
(Structure (London, England : 1993), 2014-11)The AbrB protein from Bacillus subtilis is a DNA-binding global regulator controlling the onset of a vast array of protective functions under stressful conditions. Such functions include biofilm formation, antibiotic production, ... -
The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets.
(mBio, 2020-12)Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a ...
