Now showing items 1-3 of 3

    • Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. 

      PRISM Investigators; Rowan, Kathryn M; Angus, Derek C; Bailey, Michael; Barnato, Amber E; Bellomo, Rinaldo; Canter, Ruth R; ... (24 authors) (The New England journal of medicine, 2017-06)
      BACKGROUND:After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...
    • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. 

      REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher, Ewan C; Bradbury, Charlotte A; McVerry, Bryan J; Lawler, Patrick R; ... (171 authors) (The New England journal of medicine, 2021-08-04)
      <h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes ...
    • Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. 

      ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler, Patrick R; Goligher, Ewan C; Berger, Jeffrey S; Neal, Matthew D; ... (181 authors) (The New England journal of medicine, 2021-08-04)
      <h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve ...