Now showing items 1-6 of 6

    • Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. 

      Anders, Carey K; Acharya, Chaitanya R; Hsu, David S; Broadwater, Gloria; Garman, Katherine; Foekens, John A; Zhang, Yi; ... (14 authors) (PLoS One, 2008-01-02)
      PURPOSE: To define the biology driving the aggressive nature of breast cancer arising in young women. EXPERIMENTAL DESIGN: Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts ...
    • An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer. 

      Salter, Kelly H; Acharya, Chaitanya R; Walters, Kelli S; Redman, Richard; Anguiano, Ariel; Garman, Katherine S; Anders, Carey K; ... (14 authors) (PLoS One, 2008-04-02)
      BACKGROUND: A major challenge in oncology is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality ...
    • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 

      Meadows, Sarah K; Dressman, Holly K; Daher, Pamela; Himburg, Heather; Russell, J Lauren; Doan, Phuong; Chao, Nelson J; ... (10 authors) (PLoS One, 2010-07-12)
      In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Meadows, Sarah K; Dressman, Holly K; Muramoto, Garrett G; Himburg, Heather; Salter, Alice; Wei, ZhengZheng; Ginsburg, Geoffrey S; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
    • Gene expression signatures that predict radiation exposure in mice and humans. 

      Dressman, Holly K; Muramoto, Garrett G; Chao, Nelson J; Meadows, Sarah; Marshall, Dawn; Ginsburg, Geoffrey S; Nevins, Joseph R; ... (8 authors) (PLoS Med, 2007-04)
      BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ...
    • Stochastic E2F activation and reconciliation of phenomenological cell-cycle models. 

      Lee, Tae J; Yao, Guang; Bennett, Dorothy C; Nevins, Joseph R; You, Lingchong (PLoS Biol, 2010-09-21)
      The transition of the mammalian cell from quiescence to proliferation is a highly variable process. Over the last four decades, two lines of apparently contradictory, phenomenological models have been proposed to account ...