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Browsing by Author "Newgard, Christopher B"
Now showing items 1-8 of 8
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Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.
Shah, Svati H; Bain, James R; Muehlbauer, Michael J; Stevens, Robert D; Crosslin, David R; Haynes, Carol; Dungan, Jennifer; ... (12 authors) (Circ Cardiovasc Genet, 2010-04)BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed ... -
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Huffman, Kim M; Redman, Leanne M; Landerman, Lawrence R; Pieper, Carl F; Stevens, Robert D; Muehlbauer, Michael J; Wenner, Brett R; ... (12 authors) (PLoS One, 2012)OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or ... -
Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.
Bhupathiraju, Shilpa N; Guasch-Ferré, Marta; Gadgil, Meghana D; Newgard, Christopher B; Bain, James R; Muehlbauer, Michael J; Ilkayeva, Olga R; ... (11 authors) (The Journal of nutrition, 2018-07)Recent studies, primarily in non-Hispanic whites, suggest that dietary patterns have distinct metabolomic signatures that may influence disease risk. However, evidence in South Asians, a group with unique dietary patterns ... -
Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.
Huffman, Kim M; Slentz, Cris A; Bateman, Lori A; Thompson, Dana; Muehlbauer, Michael J; Bain, James R; Stevens, Robert D; ... (11 authors) (Diabetes Care, 2011-01)OBJECTIVE: To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. ... -
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
Gerriets, Valerie A; Kishton, Rigel J; Nichols, Amanda G; Macintyre, Andrew N; Inoue, Makoto; Ilkayeva, Olga; Winter, Peter S; ... (22 authors) (J Clin Invest, 2015-01)Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific ... -
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.
Hunter, Wynn G; Kelly, Jacob P; McGarrah, Robert W; Khouri, Michel G; Craig, Damian; Haynes, Carol; Ilkayeva, Olga; ... (16 authors) (J Am Heart Assoc, 2016-07-29)BACKGROUND: Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction ... -
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
Kraus, William E; Muoio, Deborah M; Stevens, Robert; Craig, Damian; Bain, James R; Grass, Elizabeth; Haynes, Carol; ... (16 authors) (PLoS Genet, 2015-11)Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) ... -
The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.
McCann, Jessica R; Bihlmeyer, Nathan A; Roche, Kimberly; Catherine, Cameron; Jawahar, Jayanth; Kwee, Lydia Coulter; Younge, Noelle E; ... (25 authors) (Obesity (Silver Spring, Md.), 2021-03)<h4>Objective</h4>The purpose of this study was to establish a biorepository of clinical, metabolomic, and microbiome samples from adolescents with obesity as they undergo lifestyle modification.<h4>Methods</h4>A total of ...