Browsing by Author "Newpher, Thomas M"
Now showing items 1-10 of 10
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Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.
(EMBO J, 2010-09-01)Myosins-I are conserved proteins that bear an N-terminal motor head followed by a Tail Homology 1 (TH1) lipid-binding domain. Some myosins-I have an additional C-terminal extension (C(ext)) that promotes Arp2/3 complex-dependent ... -
Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast.
(Traffic (Copenhagen, Denmark), 2006-05)Clathrin is a major vesicle coat protein involved in receptor-mediated endocytosis. In yeast and higher eukaryotes, clathrin is recruited to the plasma membrane during the early stage of endocytosis along with clathrin-associated ... -
Glutamate receptor dynamics in dendritic microdomains.
(Neuron, 2008-05)Among diverse factors regulating excitatory synaptic transmission, the abundance of postsynaptic glutamate receptors figures prominently in molecular memory and learning-related synaptic plasticity. To allow for both long-term ... -
In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.
(Developmental cell, 2005-07)Clathrin-mediated transport is a major pathway for endocytosis. However, in yeast, where cortical actin patches are essential for endocytosis, plasma membrane-associated clathrin has never been observed. Using live cell ... -
Novel function of clathrin light chain in promoting endocytic vesicle formation.
(Molecular biology of the cell, 2006-10)Clathrin-mediated endocytosis is a major pathway for uptake of lipid and protein cargo at the plasma membrane. The lattices of clathrin-coated pits and vesicles are comprised of triskelions, each consisting of three oligomerized ... -
Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics
(APPLIED OPTICS, 2010-05-20) -
Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer.
(Neuron, 2007-09)Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis ... -
Regulation of spine structural plasticity by Arc/Arg3.1.
(Seminars in cell & developmental biology, 2018-05)Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information ... -
Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.
(J Cell Sci, 2012-10-15)Phosphorylation regulates assembly and disassembly of proteins during endocytosis. In yeast, Prk1 and Ark1 phosphorylate factors after vesicle internalization leading to coat disassembly. Scd5, a protein phosphatase-1 ... -
Spine microdomains for postsynaptic signaling and plasticity.
(Trends in cell biology, 2009-05)Changes in the molecular composition and signaling properties of excitatory glutamatergic synapses onto dendritic spines mediate learning-related plasticity in the mammalian brain. This molecular adaptation serves as the ...
