Browsing by Author "Nichols, Connie B"

Campafungins: Inhibitors of Candida albicans and Cryptococcus neoformans Hyphal Growth.

Perlatti, Bruno; Harris, Guy; Nichols, Connie B; Ekanayake, Dulamini I; Alspaugh, J Andrew; Gloer, James B; Bills, Gerald F (Journal of natural products, 2020-09-03)

Campafungin A is a polyketide that was recognized in the Candida albicans fitness test due to its antiproliferative and antihyphal activity. Its mode of action was hypothesized to involve inhibition of a cAMP-dependent PKA ...

Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

Esher, Shannon K; Ost, Kyla S; Kohlbrenner, Maria A; Pianalto, Kaila M; Telzrow, Calla L; Campuzano, Althea; Nichols, Connie B; ... (10 authors) (PLoS pathogens, 2018-06-04)

The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall remodeling is essential for host immune avoidance by this pathogen. ...

HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence.

Brandão, Fabiana; Esher, Shannon K; Ost, Kyla S; Pianalto, Kaila; Nichols, Connie B; Fernandes, Larissa; Bocca, Anamélia L; ... (9 authors) (Scientific reports, 2018-03-26)

The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression ...

Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis.

Perlatti, Bruno; Nichols, Connie B; Lan, Nan; Wiemann, Philipp; Harvey, Colin JB; Alspaugh, J Andrew; Bills, Gerald F (Frontiers in microbiology, 2020-01)

Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth ...

Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.

O'Meara, Teresa R; Norton, Diana; Price, Michael S; Hay, Christie; Clements, Meredith F; Nichols, Connie B; Alspaugh, J Andrew (PLoS Pathog, 2010-02-19)

Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved ...

Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis.

Esher, Shannon K; Ost, Kyla S; Kozubowski, Lukasz; Yang, Dong-Hoon; Kim, Min Su; Bahn, Yong-Sun; Alspaugh, J Andrew; ... (8 authors) (mSphere, 2016-03)

Prenyltransferase enzymes promote the membrane localization of their target proteins by directing the attachment of a hydrophobic lipid group at a conserved C-terminal CAAX motif. Subsequently, the prenylated protein is ...