Now showing items 1-6 of 6

    • Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. 

      Cho, Eugenia H; David, Lawrence Anthony; Deshusses, Marc A; Durand, Heather K; Jiang, Sharon; Klitzman, Bruce; Midani, Firas S; ... (14 authors) (eLife, 2018-06-19)
      How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed ...
    • Increased in vivo glucose recovery via nitric oxide release. 

      Klitzman, Bruce; Le, NN; Nichols, Scott P; Schoenfisch, MH (Anal Chem, 2011-02-15)
      The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant ...
    • Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia. 

      Chien, Jennifer S; Eldik, Hysem; Ibrahim, Mohamed; Klitzman, Bruce; Martinez, Jeremy; Mohammed, Mahmoud; Nichols, Scott P; ... (8 authors) (Scientific reports, 2017-08-15)
      Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood ...
    • Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia. 

      Chien, JS; Eldik, Hysem; Ibrahim, Mohamed; Klitzman, Bruce; Martinez, J; Mohammed, Mahmoud; Nichols, Scott P; ... (8 authors) (Nature Scientific Reports, 2017-08-15)
      Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood ...
    • The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. 

      Brown, NL; Klitzman, Bruce; Koh, A; Nichols, Scott P; Riccio, DA; Rose, MB; Schoenfisch, MH; ... (9 authors) (Biomaterials, 2012-09)
      Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates ...
    • Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia. 

      Klitzman, Bruce; Wisniewski, Natalie A; Nichols, Scott P; Gamsey, Soya J; Pullins, Steve; Au-Yeung, Kit Y; Helton, Kristen L (Advances in experimental medicine and biology, 2017-01)
      We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have ...