Browsing by Author "Nicolelis, Miguel AL"
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A Brain to Spine Interface for Transferring Artificial Sensory Information.
Yadav, Amol P; Li, Daniel; Nicolelis, Miguel AL (Scientific reports, 2020-01-21)Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information ... -
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Pais-Vieira, Miguel; Yadav, Amol P; Moreira, Derek; Guggenmos, David; Santos, Amílcar; Lebedev, Mikhail; Nicolelis, Miguel AL (Scientific reports, 2016-09-08)Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective ... -
Building an organic computing device with multiple interconnected brains.
Pais-Vieira, Miguel; Chiuffa, Gabriela; Lebedev, Mikhail; Yadav, Amol; Nicolelis, Miguel AL (Scientific reports, 2015-07-09)Recently, we proposed that Brainets, i.e. networks formed by multiple animal brains, cooperating and exchanging information in real time through direct brain-to-brain interfaces, could provide the core of a new type of computing ... -
Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions.
Yadav, Amol P; Fuentes, Romulo; Zhang, Hao; Vinholo, Thais; Wang, Chi-Han; Freire, Marco Aurelio M; Nicolelis, Miguel AL (Scientific reports, 2014-01-23)Although L-dopa continues to be the gold standard for treating motor symptoms of Parkinson's disease (PD), it presents long-term complications. Deep brain stimulation is effective, but only a small percentage of idiopathic ... -
Cortical neurons multiplex reward-related signals along with sensory and motor information.
Ramakrishnan, Arjun; Byun, Yoon Woo; Rand, Kyle; Pedersen, Christian E; Lebedev, Mikhail A; Nicolelis, Miguel AL (Proc Natl Acad Sci U S A, 2017-06-13)Rewards are known to influence neural activity associated with both motor preparation and execution. This influence can be exerted directly upon the primary motor (M1) and somatosensory (S1) cortical areas via the projections ... -
Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease.
Yadav, Amol P; Nicolelis, Miguel AL (Movement disorders : official journal of the Movement Disorder Society, 2017-06)Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could ... -
Spike avalanches exhibit universal dynamics across the sleep-wake cycle.
Ribeiro, Tiago L; Copelli, Mauro; Caixeta, Fábio; Belchior, Hindiael; Chialvo, Dante R; Nicolelis, Miguel AL; Ribeiro, Sidarta (PLoS One, 2010-11-30)BACKGROUND: Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between ...