Browsing by Author "Nixon, Andrew B"

Now showing items 1-3 of 3

    • A phase I study of ABT-510 plus bevacizumab in advanced solid tumors. 

      Uronis, Hope E; Cushman, Stephanie M; Bendell, Johanna C; Blobe, Gerard C; Morse, Michael A; Nixon, Andrew B; Dellinger, Andrew; ... (13 authors) (Cancer Med, 2013-06)
      Targeting multiple regulators of tumor angiogenesis have the potential to improve treatment efficacy. Bevacizumab is a monoclonal antibody directed against vascular endothelial growth factor and ABT-510 is a synthetic analog ...

    • Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines. 

      Lopez-Acevedo, Micael; Grace, Lisa; Teoh, Deanna; Whitaker, Regina; Adams, David J; Jia, Jingquan; Nixon, Andrew B; ... (8 authors) (Gynecol Oncol Res Pract, 2014)
      BACKGROUND: To explore the activity of dasatinib alone and in combination with gemcitabine and docetaxel in uterine leiomyosarcoma (uLMS) cell lines, and determine if dasatinib inhibits the SRC pathway. METHODS: SK-UT-1 ...

    • Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. 

      Hanks, Brent A; Holtzhausen, Alisha; Evans, Katherine S; Jamieson, Rebekah; Gimpel, Petra; Campbell, Olivia M; Hector-Greene, Melissa; ... (20 authors) (J Clin Invest, 2013-09)
      Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that ...