Now showing items 1-2 of 2

    • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 

      Casaletto, Jessica B; Nutt, Leta K; Wu, Qiju; Moore, Jonathan D; Etkin, Laurence D; Jackson, Peter K; Hunt, Tim; ... (8 authors) (J Cell Biol, 2005-04-11)
      Degradation of specific protein substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit. We have identified the protein Xenopus nuclear factor 7 (Xnf7) as a novel APC inhibitor able to regulate ...
    • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 

      Zhu, Wenge; Ukomadu, Chinweike; Jha, Sudhakar; Senga, Takeshi; Dhar, Suman K; Wohlschlegel, James A; Nutt, Leta K; ... (9 authors) (Genes Dev, 2007-09-15)
      The MCM2-7 helicase complex is loaded on DNA replication origins during the G1 phase of the cell cycle to license the origins for replication in S phase. How the initiator primase-polymerase complex, DNA polymerase alpha ...