Browsing by Author "Parrish, AB"

Now showing items 1-1 of 1

Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.

Johnson, CE; Huang, YY; Parrish, AB; Smith, MI; Vaughn, AE; Zhang, Q; Wright, KM; ... (11 authors) (Proc Natl Acad Sci U S A, 2007-12-26)

Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream ...