Browsing by Author "Perfect, JR"

Now showing items 1-4 of 4

    • Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. 

      Janbon, G; Ormerod, KL; Paulet, D; Byrnes, EJ; Yadav, V; Chatterjee, G; Mullapudi, N; ... (52 authors) (PLoS Genet, 2014-04)
      Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ...

    • Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study. 

      Johnson, MD; Plantinga, TS; van de Vosse, E; Velez Edwards, DR; Smith, PB; Alexander, BD; Yang, JC; ... (18 authors) (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012-02)
      BACKGROUND:  Candida bloodstream infections cause significant morbidity and mortality among hospitalized patients. Although clinical and microbiological factors affecting prognosis have been identified, the impact of genetic ...

    • Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. 

      Schell, WA; Benton, JL; Smith, PB; Poore, M; Rouse, JL; Boles, DJ; Johnson, MD; ... (14 authors) (Eur J Clin Microbiol Infect Dis, 2012-09)
      Species of Candida frequently cause life-threatening infections in neonates, transplant and intensive care unit (ICU) patients, and others with compromised host defenses. The successful management of systemic candidiasis ...

    • The impact of caspase-12 on susceptibility to candidemia. 

      Rosentul, DC; Plantinga, TS; Scott, WK; Alexander, BD; van de Geer, NMD; Perfect, JR; Kullberg, BJ; ... (9 authors) (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012-03)
      Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been ...