Now showing items 1-11 of 11

    • ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. 

      Lee, Stella Y; Yang, Jia-Shu; Hong, Wanjin; Premont, Richard T; Hsu, Victor W (J Cell Biol, 2005-01-17)
      Examining how key components of coat protein I (COPI) transport participate in cargo sorting, we find that, instead of ADP ribosylation factor 1 (ARF1), its GTPase-activating protein (GAP) plays a direct role in promoting ...
    • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. 

      Yang, Jia-Shu; Lee, Stella Y; Gao, Minggeng; Bourgoin, Sylvain; Randazzo, Paul A; Premont, Richard T; Hsu, Victor W (J Cell Biol, 2002-10-14)
      The role of GTPase-activating protein (GAP) that deactivates ADP-ribosylation factor 1 (ARF1) during the formation of coat protein I (COPI) vesicles has been unclear. GAP is originally thought to antagonize vesicle formation ...
    • Consensus nomenclature for the human ArfGAP domain-containing proteins. 

      Kahn, Richard A; Bruford, Elspeth; Inoue, Hiroki; Logsdon, John M; Nie, Zhongzhen; Premont, Richard T; Randazzo, Paul A; ... (11 authors) (J Cell Biol, 2008-09-22)
      At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has ...
    • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 

      Fong, Alan M; Premont, Richard T; Richardson, Ricardo M; Yu, Yen-Rei A; Lefkowitz, Robert J; Patel, Dhavalkumar D (Proc Natl Acad Sci U S A, 2002-05-28)
      Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
    • Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. 

      Siddiqui, Sana; Lustig, Ana; Carter, Arnell; Sankar, Mathavi; Daimon, Caitlin M; Premont, Richard T; Etienne, Harmonie; ... (18 authors) (Aging (Albany NY), 2017-03-04)
      Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks ...
    • GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. 

      Martin, Bronwen; Chadwick, Wayne; Janssens, Jonathan; Premont, Richard T; Schmalzigaug, Robert; Becker, Kevin G; Lehrmann, Elin; ... (14 authors) (Front Endocrinol (Lausanne), 2015)
      Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system ...
    • GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability. 

      He, Minchao; Singh, Prabhakar; Cheng, Shaowu; Zhang, Qiang; Peng, Wei; Ding, XueFeng; Li, Longxuan; ... (13 authors) (Sci Rep, 2016-05-19)
      Why certain diseases primarily affect one specific neuronal subtype rather than another is a puzzle whose solution underlies the development of specific therapies. Selective basal forebrain cholinergic (BFC) neurodegeneration ...
    • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 

      Oh, Seh-Hoon; Swiderska-Syn, Marzena; Jewell, Mark L; Premont, Richard T; Diehl, Anna Mae (Journal of hepatology, 2018-05-11)
      Chronic failure of mechanisms that promote effective regeneration of dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar and ultimately results in cirrhosis. Therefore, defining and optimizing ...
    • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 

      Xie, Guanhua; Swiderska-Syn, Marzena; Jewell, Mark L; Machado, Mariana Verdelho; Michelotti, Gregory A; Premont, Richard T; Diehl, Anna Mae (BMC Cell Biol, 2017-04-20)
      BACKGROUND: Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy availability ...
    • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 

      Michelotti, Gregory A; Tucker, Anikia; Swiderska-Syn, Marzena; Machado, Mariana Verdelho; Choi, Steve S; Kruger, Leandi; Soderblom, Erik; ... (16 authors) (Gut, 2016-04)
      OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. ...
    • The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. 

      Managò, Francesca; Espinoza, Stefano; Salahpour, Ali; Sotnikova, Tatyana D; Caron, Marc G; Premont, Richard T; Gainetdinov, Raul R (Sci Rep, 2012)
      G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice ...