Browsing by Author "Purves, J Todd"
Now showing items 1-12 of 12
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A three dimensional nerve map of human bladder trigone.
(Neurourology and urodynamics, 2017-04)Central efferent and afferent neural pathways to and from the human urinary bladder are well-characterized, but the location and arborization of these nerves as they traverse the serosa, muscularis, and urothelial layers ... -
Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.
(American journal of physiology. Renal physiology, 2017-09)Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible for the decompensation of the bladder in the chronic state. ... -
Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP.
(Research and reports in urology, 2019-01)Objective:To investigate the in vitro activation of the NLRP3 inflammasome within bladder urothelium by stone-forming components. Further, to describe the contributions of reactive oxygen species (ROS) and thioredoxin-interacting ... -
Delayed presentation of urethrocutaneous fistulae after hypospadias repair.
(Journal of pediatric surgery, 2020-01-29)BACKGROUND:Delayed urethrocutaneous fistula (UCF) presentation after hypospadias repair is rarely reported. The aim of this study is to report our experience with delayed UCF presenting more than 5 years after hypospadias ... -
Inflammasomes in the urinary tract: a disease-based review.
(American journal of physiology. Renal physiology, 2016-10)Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response, most commonly through production of the proinflammatory cytokines ... -
Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.
(Frontiers in physiology, 2022-01)Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by 2050. This disease is characterized by devastating complications brought about high glucose and metabolic derangement. The most ... -
NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
(Neurourology and urodynamics, 2018-03)Denervation of the bladder is a detrimental consequence of bladder outlet obstruction (BOO). We have previously shown that, during BOO, inflammation triggered by the NLRP3 inflammasome in the urothelia mediates physiological ... -
Parental Preferences for Vesicoureteral Reflux Treatment: a Crowd-sourced, Best-worst Scaling Study.
(Urology, 2019-03-13)OBJECTIVE:To quantitatively evaluate parental preferences for the various treatments for vesicoureteral reflux using crowd-sourced best-worst scaling, a novel technique in urologic preference estimation. METHODS:Preference ... -
The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology.
(Current urology, 2018-02)Irritative voiding symptoms (e.g. increased frequency and urgency) occur in many common pathologic conditions such as urinary tract infections and bladder outlet obstruction, and these conditions are well-established to ... -
The Importance of Early Diagnosis and Management of Pediatric Neurogenic Bladder Dysfunction.
(Research and reports in urology, 2021-01)Neurogenic bladder dysfunction is a major source of urologic morbidity in children, especially in those with spina bifida (SB). Complications from progression of bladder dysfunction can include urinary tract infections (UTIs), ... -
The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.
(The Journal of urology, 2016-05)While bladder outlet obstruction is well established to elicit an inflammatory reaction in the bladder that leads to overactive bladder and fibrosis, little is known about the mechanism by which this is initiated. NLRs (NOD-like ... -
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.
(International journal of molecular sciences, 2023-02)Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population and recent prospective studies ...
