Now showing items 1-2 of 2

    • Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling. 

      Goodwin, Courtney Rory; Hayward, SD; Hu, J; Laterra, J; Newman, R; Qian, J; Wan, J; ... (11 authors) (PLoS One, 2013)
      Protein phosphorylation is a dynamic and reversible event that greatly influences cellular function. Identifying the key regulatory elements that determine cellular phenotypes during development and oncogenesis requires ...
    • Visualization of arrestin recruitment by a G-protein-coupled receptor. 

      Blanc, A; Chen, X; Choi, M; Dosey, AM; Gu, LL; Hanna, R; Huang, Li-Yin; ... (29 authors) (Nature, 2014-08-14)
      G-protein-coupled receptors (GPCRs) are critically regulated by β-arrestins, which not only desensitize G-protein signalling but also initiate a G-protein-independent wave of signalling. A recent surge of structural data ...