Browsing by Author "Que, Loretta G"
Now showing items 1-13 of 13
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Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative LEEP Trial.
(American journal of respiratory and critical care medicine, 2022-06)<h4>Rationale</h4>There are no pharmacologic agents that modify emphysema progression in patients with chronic obstructive pulmonary disease (COPD).<h4>Objective</h4>Evaluate the efficacy of losartan, an angiotensin receptor ... -
Combining Heparin and a FX/Xa Aptamer to Reduce Thrombin Generation in Cardiopulmonary Bypass and COVID-19.
(Nucleic acid therapeutics, 2022-01-12)Known limitations of unfractionated heparin (UFH) have encouraged the evaluation of anticoagulant aptamers as alternatives to UFH in highly procoagulant settings such as cardiopulmonary bypass (CPB). Despite progress, these ... -
Control of antiviral innate immune response by protein geranylgeranylation
(Science Advances, 2019-05)<jats:p>The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing ... -
Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.
(Journal of asthma and allergy, 2021-01)Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, TH2 driven inflammation. Landmark studies in the second half of the twentieth century ... -
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
(Immunity, inflammation and disease, 2018-06)<h4>Rationale</h4>Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR.<h4>Objectives</h4>An exploratory proof of concept clinical study of N6022 in mild asthma to determine ... -
Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.
(Respiratory research, 2022-05-24)<h4>Background</h4>Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that ... -
Immuno-fibrotic drivers of impaired lung function in post-COVID-19 syndrome.
(medRxiv, 2021-02-06)Introduction: Subjects recovering from COVID-19 frequently experience persistent respiratory ailments; however, little is known about the underlying biological factors that may direct lung recovery and the extent to which ... -
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.
(JCI insight, 2021-07-22)BACKGROUNDIndividuals recovering from COVID-19 frequently experience persistent respiratory ailments, which are key elements of postacute sequelae of SARS-CoV-2 infection (PASC); however, little is known about the underlying ... -
Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.
(A&A practice, 2021-03-30)The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We report a 53-year-old man presenting with acute leukemia and COVID-19 ... -
Obesity and Asthma.
(Seminars in respiratory and critical care medicine, 2022-02-17)Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma-recent studies in the United ... -
Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.
(Journal of global health, 2021-05-08)<h4>Background</h4>Respiratory diseases are the leading cause of death and disability worldwide. Oxygen is an essential medicine used to treat hypoxemia from respiratory diseases. However, the availability and utilization ... -
SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.
(Journal of immunology (Baltimore, Md. : 1950), 2012-04)Asthma is a chronic inflammatory disease in which airway epithelial cells are the first line of defense against exposure of the airway to infectious agents. Src homology protein (SHP)-1, a protein tyrosine phosphatase, is ... -
Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma An Official American Thoracic Society Clinical Practice Guideline: Executive Summary
(AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021-11-15)
