Now showing items 1-4 of 4

    • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 

      Rock, Jason R; Randell, Scott H; Hogan, Brigid LM (Dis Model Mech, 2010-09)
      The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. These clinical problems ...
    • Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. 

      Katsura, Hiroaki; Sontake, Vishwaraj; Tata, Aleksandra; Kobayashi, Yoshihiko; Edwards, Caitlin E; Heaton, Brook E; Konkimalla, Arvind; ... (16 authors) (Cell stem cell, 2020-10-21)
      Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an understanding of coronavirus disease 2019 (COVID-19) ...
    • Type 2 alveolar cells are stem cells in adult lung. 

      Barkauskas, Christina E; Cronce, Michael J; Rackley, Craig R; Bowie, Emily J; Keene, Douglas R; Stripp, Barry R; Randell, Scott H; ... (9 authors) (The Journal of clinical investigation, 2013-07)
      Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo ...
    • UHRF1 is required for basal stem cell proliferation in response to airway injury. 

      Xiang, Handan; Yuan, Lifeng; Gao, Xia; Alexander, Peter B; Lopez, Omar; Lau, Calvin; Ding, Yi; ... (16 authors) (Cell Discov, 2017)
      Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence ...