Now showing items 1-3 of 3

    • A high-resolution map of human evolutionary constraint using 29 mammals. 

      Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F; Parker, Brian J; Washietl, Stefan; Kheradpour, Pouya; ... (89 authors) (Nature, 2011-10-12)
      The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome ...
    • Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes. 

      St John, John A; Braun, Edward L; Isberg, Sally R; Miles, Lee G; Chong, Amanda Y; Gongora, Jaime; Dalzell, Pauline; ... (48 authors) (Genome Biol, 2012-01-31)
      The International Crocodilian Genomes Working Group (ICGWG) will sequence and assemble the American alligator (Alligator mississippiensis), saltwater crocodile (Crocodylus porosus) and Indian gharial (Gavialis gangeticus) ...
    • Three periods of regulatory innovation during vertebrate evolution. 

      Lowe, Craig B; Kellis, Manolis; Siepel, Adam; Raney, Brian J; Clamp, Michele; Salama, Sofie R; Kingsley, David M; ... (9 authors) (Science (New York, N.Y.), 2011-08)
      The gain, loss, and modification of gene regulatory elements may underlie a substantial proportion of phenotypic changes on animal lineages. To investigate the gain of regulatory elements throughout vertebrate evolution, ...