Now showing items 1-9 of 9

    • An integrated transcriptome and expressed variant analysis of sepsis survival and death. 

      Tsalik, Ephraim L; Langley, Raymond J; Dinwiddie, Darrell L; Miller, Neil A; Yoo, Byunggil; van Velkinburgh, Jennifer C; Smith, Laurie D; ... (24 authors) (Genome Med, 2014)
      BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ...
    • Comparing the Diagnostic Accuracy of Clinician Judgment to a Novel Host Response Diagnostic for Acute Respiratory Illness. 

      Jaffe, Ian S; Jaehne, Anja K; Quackenbush, Eugenia; Ko, Emily R; Rivers, Emanuel P; McClain, Micah T; Ginsburg, Geoffrey S; ... (9 authors) (Open forum infectious diseases, 2021-12)
      <h4>Background</h4>Difficulty discriminating bacterial from viral infections drives antibacterial misuse. Host gene expression tests discriminate bacterial and viral etiologies, but their clinical utility has not ...
    • Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test. 

      Tsalik, Ephraim L; Henao, Ricardo; Montgomery, Jesse L; Nawrocki, Jeff W; Aydin, Mert; Lydon, Emily C; Ko, Emily R; ... (24 authors) (Critical care medicine, 2021-10)
      <h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ...
    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

      Ahn, Sun Hee; Tsalik, Ephraim L; Cyr, Derek D; Zhang, Yurong; van Velkinburgh, Jennifer C; Langley, Raymond J; Glickman, Seth W; ... (18 authors) (PLoS One, 2013)
      Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
    • Host gene expression classifiers diagnose acute respiratory illness etiology. 

      Tsalik, Ephraim L; Henao, Ricardo; Nichols, Marshall; Burke, Thomas; Ko, Emily R; McClain, Micah T; Hudson, Lori L; ... (24 authors) (Sci Transl Med, 2016-01-20)
      Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
    • Metabolomic derangements are associated with mortality in critically ill adult patients. 

      Rogers, Angela J; McGeachie, Michael; Baron, Rebecca M; Gazourian, Lee; Haspel, Jeffrey A; Nakahira, Kiichi; Fredenburgh, Laura E; ... (18 authors) (PLoS One, 2014)
      OBJECTIVE: To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. RATIONALE: Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with ...
    • Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection. 

      Ko, Emily R; Henao, Ricardo; Frankey, Katherine; Petzold, Elizabeth A; Isner, Pamela D; Jaehne, Anja K; Allen, Nakia; ... (36 authors) (JAMA network open, 2022-04)
      <h4>Importance</h4>Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based ...
    • Renal systems biology of patients with systemic inflammatory response syndrome. 

      Tsalik, Ephraim L; Willig, Laurel K; Rice, Brandon J; van Velkinburgh, Jennifer C; Mohney, Robert P; McDunn, Jonathan E; Dinwiddie, Darrell L; ... (21 authors) (Kidney Int, 2015-10)
      A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...
    • Validation of a host response test to distinguish bacterial and viral respiratory infection. 

      Lydon, Emily C; Henao, Ricardo; Burke, Thomas W; Aydin, Mert; Nicholson, Bradly P; Glickman, Seth W; Fowler, Vance G; ... (19 authors) (EBioMedicine, 2019-10-17)
      BACKGROUND:Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform ...