Now showing items 1-2 of 2

    • Regulated spindle orientation buffers tissue growth in the epidermis. 

      Morrow, Angel; Underwood, Julie; Seldin, Lindsey; Hinnant, Taylor; Lechler, Terry (eLife, 2019-10)
      Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle ...
    • The Role of Spindle Orientation in Epidermal Development and Homeostasis 

      Seldin, Lindsey (2015)
      Robust regulation of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic ...