Browsing by Author "Shenoy, Sudha K"
Now showing items 1-5 of 5
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beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ... -
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
(Proc Natl Acad Sci U S A, 2003-09-16)Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang II) fails to activate classical heterotrimeric G protein ... -
Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.
(Cardiovasc Res, 2017-11-01)Aims: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates ... -
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.
(Scientific reports, 2016-09-27)On Earth, biological systems have evolved in response to environmental stressors, interactions dictated by physical forces that include gravity. The absence of gravity is an extreme stressor and the impact of its absence ... -
Trafficking of G protein-coupled receptors.
(Circ Res, 2006-09-15)G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. ...
