Browsing by Author "Siegler, Ilene C"
Now showing items 1-14 of 14
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A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
(PLoS One, 2013)Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress ... -
A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.
(PloS one, 2014-01)Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive ... -
Changes in neuroticism following trauma exposure.
(J Pers, 2014-04)Using longitudinal data, the present study examined change in midlife neuroticism following trauma exposure. Our primary analyses included 670 participants (M(age) = 60.55; 65.22% male, 99.70% Caucasian) who completed the ... -
Commentary-Pre- and Posttrauma Predictors of Posttraumatic Stress Disorder Symptom Severity: Reply to van der Velden and van der Knaap (2017).
(Clinical psychological science : a journal of the Association for Psychological Science, 2017-01) -
Cumulative exposure to traumatic events in older adults.
(Aging Ment Health, 2014)OBJECTIVES: The present study examined the impact of cumulative trauma exposure on current posttraumatic stress disorder (PTSD) symptom severity in a nonclinical sample of adults in their 60s. The predictive utility of cumulative ... -
Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.
(Translational psychiatry, 2020-10-20)In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our ... -
Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.
(Frontiers in genetics, 2018-01)The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. ... -
Neuroticism Increases PTSD Symptom Severity by Amplifying the Emotionality, Rehearsal, and Centrality of Trauma Memories.
(Journal of personality, 2017-10)OBJECTIVE:Although it is well established that neuroticism increases the risk of posttraumatic stress disorder (PTSD), little is known about the mechanisms that promote PTSD in individuals with elevated levels of neuroticism. ... -
Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.
(SSM - population health, 2019-12)The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work ... -
The Frequency and Impact of Exposure to Potentially Traumatic Events Over the Life Course.
(Clin Psychol Sci, 2013-10-01)We examined the frequency and impact of exposure to potentially traumatic events among a nonclinical sample of older adults (n = 3,575), a population typically underrepresented in epidemiological research concerning the ... -
The impact of the developmental timing of trauma exposure on PTSD symptoms and psychosocial functioning among older adults.
(Dev Psychol, 2013-11)The present study examined the impact of the developmental timing of trauma exposure on posttraumatic stress disorder (PTSD) symptoms and psychosocial functioning in a large sample of community-dwelling older adults (N = ... -
The relation between insecure attachment and posttraumatic stress: Early life versus adulthood traumas.
(Psychological trauma : theory, research, practice and policy, 2015-07)The present study examined the relations between insecure attachment and posttraumatic stress disorder (PTSD) symptoms among community-dwelling older adults with exposure to a broad range of traumatic events. Attachment ... -
The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.
(Biol Psychol, 2012-09)Here we examine the effects of both self-reported and independent observer-reported environmental risk indices, the serotonin transporter gene promoter (5HTTLPR) polymorphism, and their interaction on self-esteem. This trait ... -
Two versions of life: emotionally negative and positive life events have different roles in the organization of life story and identity.
(Emotion, 2011-10)Over 2,000 adults in their sixties completed the Centrality of Event Scale (CES) for the traumatic or negative event that now troubled them the most and for their most positive life event, as well as measures of current ...
