Browsing by Author "Skiba, Nikolai P"
Now showing items 1-4 of 4
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Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.
(Investigative ophthalmology & visual science, 2017-06)Complement activation is implicated in the pathogenesis of age-related macular degeneration (AMD). Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in ... -
Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
(Scientific reports, 2017-07-07)The retinal pigmented epithelium (RPE) forms the outer blood-retinal barrier in the eye and its polarity is responsible for directional secretion and uptake of proteins, lipoprotein particles and extracellular vesicles (EVs). ... -
Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
(Nature communications, 2018-04-30)Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent, i.e., ... -
Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.
(eNeuro, 2018-05)The heterotrimeric G-protein transducin mediates visual signaling in vertebrate photoreceptor cells. Many aspects of the function of transducin were learned from knock-out mice lacking its individual subunits. Of particular ...
