Browsing by Author "Soderblom, Erik J"
Now showing items 1-15 of 15
-
A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA.
(Journal of molecular biology, 2014-05)Bacteria respond to adverse environmental conditions by switching on the expression of large numbers of genes that enable them to adapt to unfavorable circumstances. In Bacillus subtilis, many adaptive genes are under the ... -
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ... -
A novel glycoproteomics workflow reveals dynamic O-GlcNAcylation of COPγ1 as a candidate regulator of protein trafficking
(Frontiers in Endocrinology, 2018-10-15)Copyright © 2018 Cox, Luo, Smith, Bisnett, Soderblom and Boyce. O-linked ß-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation ... -
Calcineurin Targets Involved in Stress Survival and Fungal Virulence.
(PLoS Pathog, 2016-09)Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels caused by stress, and transduces signals ... -
Convergent transcriptional specializations in the brains of humans and song-learning birds.
(Science, 2014-12-12)Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes ... -
Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
(Biochemistry, 2018-01)The COPII coat complex, which mediates secretory cargo trafficking from the endoplasmic reticulum, is a key control point for subcellular protein targeting. Because misdirected proteins cannot function, protein sorting by ... -
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees.
(Genome Biol Evol, 2015-07-10)Although transcriptomic profiling has become the standard approach for exploring molecular differences in the primate brain, very little is known about how the expression levels of gene transcripts relate to downstream protein ... -
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
(eLife, 2021-03-22)Mutation of the Wiskott-Aldrich syndrome protein and SCAR homology (WASH) complex subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this association is unknown. We identify the neuronal ... -
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.
(Nature communications, 2018-12-05)The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells ... -
Microproteomics: quantitative proteomic profiling of small numbers of laser-captured cells.
(Cold Spring Harb Protoc, 2011-02-01) -
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
(PLoS One, 2014)The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development ... -
Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation.
(Clin Proteomics, 2013-01-03)UNLABELLED: BACKGROUND: In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood ... -
Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
(Proceedings of the National Academy of Sciences of the United States of America, 2018-06)O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects ... -
Structure and DNA-binding traits of the transition state regulator AbrB.
(Structure (London, England : 1993), 2014-11)The AbrB protein from Bacillus subtilis is a DNA-binding global regulator controlling the onset of a vast array of protective functions under stressful conditions. Such functions include biofilm formation, antibiotic production, ... -
The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets.
(mBio, 2020-12)Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a ...
