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Browsing by Author "Somarelli, Jason A"
Now showing items 1-5 of 5
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Alternative splicing in multiple sclerosis and other autoimmune diseases.
(RNA Biol, 2010-07)Alternative splicing is a general mechanism for regulating gene expression that affects the RNA products of more than 90% of human genes. Not surprisingly, alternative splicing is observed among gene products of metazoan ... -
Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.
(Prostate cancer and prostatic diseases, 2021-10-13)<h4>Background</h4>Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models ... -
Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.
(Mol Cell Biol, 2016-10-01)Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-mesenchymal transition (EMT) and ... -
Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.
(Molecular cancer therapeutics, 2020-07)Therapeutic advances for osteosarcoma have stagnated over the past several decades, leading to an unmet clinical need for patients. The purpose of this study was to develop a novel therapy for osteosarcoma by reformulating ... -
Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.
(Oncotarget, 2016-08-02)Treatment with androgen-targeted therapies can induce upregulation of epithelial plasticity pathways. Epithelial plasticity is known to be important for metastatic dissemination and therapeutic resistance. The goal of this ...
