Browsing by Author "Sweeney, Timothy E"

Now showing items 1-3 of 3

    • A community approach to mortality prediction in sepsis via gene expression analysis. 

      Sweeney, Timothy E; Perumal, Thanneer M; Henao, Ricardo; Nichols, Marshall; Howrylak, Judith A; Choi, Augustine M; Bermejo-Martin, Jesús F; ... (26 authors) (Nature communications, 2018-02)
      Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and ...

    • Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. 

      Suliman, Hagir B; Sweeney, Timothy E; Withers, Crystal M; Piantadosi, Claude A (J Cell Sci, 2010-08-01)
      The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS), which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation of mitochondrial biogenesis. To test this ...

    • Sepsis Subclasses: A Framework for Development and Interpretation. 

      DeMerle, Kimberley M; Angus, Derek C; Baillie, J Kenneth; Brant, Emily; Calfee, Carolyn S; Carcillo, Joseph; Chang, Chung-Chou H; ... (30 authors) (Critical care medicine, 2021-05)
      Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based ...