Now showing items 1-4 of 4

    • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 

      Oh, Seh-Hoon; Swiderska-Syn, Marzena; Jewell, Mark L; Premont, Richard T; Diehl, Anna Mae (Journal of hepatology, 2018-05-11)
      Chronic failure of mechanisms that promote effective regeneration of dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar and ultimately results in cirrhosis. Therefore, defining and optimizing ...
    • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 

      Xie, Guanhua; Swiderska-Syn, Marzena; Jewell, Mark L; Machado, Mariana Verdelho; Michelotti, Gregory A; Premont, Richard T; Diehl, Anna Mae (BMC Cell Biol, 2017-04-20)
      BACKGROUND: Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy availability ...
    • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 

      Michelotti, Gregory A; Tucker, Anikia; Swiderska-Syn, Marzena; Machado, Mariana Verdelho; Choi, Steve S; Kruger, Leandi; Soderblom, Erik; ... (16 authors) (Gut, 2016-04)
      OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. ...
    • TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. 

      Karaca, Gamze; Swiderska-Syn, Marzena; Xie, Guanhua; Syn, Wing-Kin; Krüger, Leandi; Machado, Mariana Verdelho; Garman, Katherine; ... (12 authors) (PLoS One, 2014)
      BACKGROUND & AIMS: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis ...